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Radiother Oncol. 2007 Sep;84(3):266-71. Epub 2007 Aug 22.

Conformal radiation therapy for portal vein tumor thrombosis of hepatocellular carcinoma.

Author information

1
Department of Radiation Oncology, Kumamoto University Hospital, Honjo, Kumamoto, Japan. ryo108@m9.dion.ne.jp

Abstract

BACKGROUND AND PURPOSE:

The prognosis of patients with portal vein tumor thrombosis (PVTT) from hepatocellular carcinoma (HCC) is poor; without treatment, their survival is less than 3months. We retrospectively evaluated the treatment outcomes of conformal radiation therapy (CRT) in patients with HCC-PVTT.

MATERIALS AND METHODS:

Thirty-eight HCC patients with PVTT in whom other treatment modalities were not indicated underwent CRT. The total dose was translated into a biologic effective dose (BED) of 23.4-59.5Gy(10) (median 50.7Gy(10)) as the alpha/beta ratio=10. Predictive factors including the age, performance status, Child-Pugh classification, PVTT size, and BED were evaluated for tumor response and survival.

RESULTS:

Complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were observed in 6 (15.8%), 11 (28.9%), 17 (44.7%), and 4 (10.5%) patients, respectively. The response rate (CR+PR) was 44.7%. The PVTT size (<30 vs. 30mm) and BED (<58 vs. 58Gy(10)) were significant factors for tumor response. The median survival and 1-year survival rate were 9.6months and 39.4%. The Child-Pugh classification (A vs. B) and BED were significant factors for survival.

CONCLUSIONS:

CRT is effective not only for tumor response but also for survival in HCC-PVTT patients in whom other treatment modalities are not indicated.

PMID:
17716760
DOI:
10.1016/j.radonc.2007.07.005
[Indexed for MEDLINE]

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