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Nanomedicine (Lond). 2007 Apr;2(2):153-67.

Targeted delivery of multifunctional magnetic nanoparticles.

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Center for Molecular Imaging Research, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Rm 5406, Charlestown, MA 02129, USA.


Magnetic nanoparticles and their magnetofluorescent analogues have become important tools for in vivo imaging using magnetic resonance imaging and fluorescent optical methods. A number of monodisperse magnetic nanoparticle preparations have been developed over the last decade for angiogenesis imaging, cancer staging, tracking of immune cells (monocyte/macrophage, T cells) and for molecular and cellular targeting. Phage display and data mining have enabled the procurement of novel tissue- or receptor-specific peptides, while high-throughput screening of diversity-oriented synthesis libraries has identified small molecules that permit or prevent uptake by specific cell types. Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities.

[Indexed for MEDLINE]

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