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J Org Chem. 2007 Sep 14;72(19):7343-51. Epub 2007 Aug 23.

Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.

Author information

1
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Abstract

Callophycoic acids A-H (1-8) and callophycols A and B (9 and 10) were isolated from extracts of the Fijian red alga Callophycus serratus, and identified by NMR, X-ray, and mass spectral analyses. These natural products represent four novel carbon skeletons, providing the first examples of diterpene-benzoic acids and diterpene-phenols in macroalgae. Compounds 1-10 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive than diterpene-benzoate macrolides previously isolated from this red alga.

PMID:
17715978
PMCID:
PMC3374858
DOI:
10.1021/jo071210y
[Indexed for MEDLINE]
Free PMC Article

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