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Arch Dis Child. 2007 Sep;92(9):750-3.

High prevalence of vitamin D deficiency in newborn infants of high-risk mothers.

Author information

1
Sint Franciscus Gasthuis, Rotterdam, the Netherlands.

Erratum in

  • Arch Dis Child. 2007 Nov;92(11):1049.

Abstract

OBJECTIVE:

To determine the prevalence of vitamin D deficiency in newborn infants of mothers at risk of vitamin D deficiency because of dark skin or the wearing of concealing clothes (such as a veil) compared with a group presumed not to be at risk. A second aim was to correlate these newborn infants' vitamin D concentrations with biochemical parameters of vitamin D metabolism and bone turnover at birth.

DESIGN:

A prospective study conducted between April 2004 and February 2006 including women delivering during this period and their newborn infants.

SETTING:

The outpatient clinic of the obstetrics department, Sint Franciscus Gasthuis, Rotterdam, the Netherlands.

PATIENTS:

Eighty seven newborn infants of healthy mothers with either dark skin and/or concealing clothing (risk group) or light skin (control group).

RESULTS:

We found a significant difference in the prevalence of vitamin D deficiency (25-hydroxyvitamin D(3) <25 nmol/l) between newborn infants of mothers at risk and those of mothers in the control group (63.3% vs 15.8%; p<0.001). Mean alkaline phosphatase concentrations were significantly higher in the at risk group.

CONCLUSIONS:

Newborn infants of mothers with dark skin or wearing concealing clothes are at great risk of vitamin D deficiency at birth. The clinical implications are unknown. Further research is necessary to determine the long-term consequences of maternal and neonatal vitamin D deficiency so that guidelines on vitamin D supplementation during pregnancy can be issued.

PMID:
17715438
PMCID:
PMC2084031
DOI:
10.1136/adc.2006.105577
[Indexed for MEDLINE]
Free PMC Article
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