Format

Send to

Choose Destination
J Virol. 2007 Nov;81(21):12077-9. Epub 2007 Aug 22.

Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.

Author information

1
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.

Abstract

Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the more severe the defects in viral replication and DNA synthesis, suggesting that DNA binding by UL42 is important for these processes.

PMID:
17715219
PMCID:
PMC2168780
DOI:
10.1128/JVI.01133-07
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center