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Parasitology. 2007 Dec;134(Pt.14):1911-29. Epub 2007 Aug 23.

Proteins of the malaria parasite sexual stages: expression, function and potential for transmission blocking strategies.

Author information

1
University of Würzburg, Research Center for Infectious Diseases, Röntgenring 11, 97070 Würzburg, Germany. gabriele.pradel@mail.uni-wuerzbug.de

Abstract

The sexual phase of the malaria pathogen, Plasmodium falciparum, culminates in fertilization within the midgut of the mosquito and represents a crucial step in the completion of the parasite's life-cycle and transmission of the disease. Two decades ago, the first sexual stage-specific surface proteins were identified, among them Pfs230, Pfs48/45, and Pfs25, which were of scientific interest as candidates for the development of transmission blocking vaccines. A decade later, gene information gained from the sequencing of the P. falciparum genome led to the identification of numerous additional sexual-stage proteins with antigenic properties and novel enzymes that putatively possess regulatory functions during sexual-stage development. This review aims to summarize the sexual-stage proteins identified to date, to compare their stage specificities and expression patterns and to highlight novel regulative mechanisms of sexual differentiation. The prospective candidacy of select sexual-stage proteins as targets for transmission blocking strategies will be discussed.

PMID:
17714601
DOI:
10.1017/S0031182007003381
[Indexed for MEDLINE]

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