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FEMS Microbiol Lett. 2007 Oct;275(2):244-9. Epub 2007 Aug 22.

In silico comparison of pKLC102-like genomic islands of Pseudomonas aeruginosa.

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Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, Hannover, Germany.


The genomic island pKLC102 first detected in Pseudomonas aeruginosa clone C strains can cross species barriers and exhibits the highest mobilization rate of a genomic island known to date. Homologous genomic islands of 81-108 kb in size were identified in the completely sequenced P. aeruginosa strains PA7, PA14, 2192, C3719 and PACS2, but not in strains PAO1 and LES. All pKLC102-like genomic islands are integrated in chromosomal tRNA(Lys) genes and share a syntenic set of more than 70 homologous ORFs, part of which are related to DNA replication or mobility genes. The conserved backbone has predilection sites for the uptake of island-specific gene cassettes. A major difference between the islands is the organization of the origin of replication oriV.

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