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Childs Nerv Syst. 2008 Feb;24(2):245-51. Epub 2007 Aug 22.

ICP and CPP: excellent predictors of long term outcome in severely brain injured children.

Author information

1
Paediatric Intensive Care Unit, Royal Children's Hospital, Flemington Rd, Parkville, Melbourne, Victoria, 3052, Australia. icu.tech@rch.org.au

Abstract

OBJECTIVE:

To determine the predictive powers of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) amongst severely brain injured children.

MATERIALS AND METHODS:

ICP and CPP were recorded from thirty-five severely brain injured children who were prospectively recruited after admission to paediatric intensive care. Twenty-five suffered traumatic brain injury (TBI) and ten suffered non-TBI. Peak ICP and minimum CPP recorded for each patient during their admission were related to 5 year Glasgow Outcome Scale outcome. Receiver operator characteristic curves determined that the optimum threshold for unfavourable outcome prediction was >or=40 mmHg for ICP and <or=49 mmHg for CPP. At these thresholds the sensitivity/specificity pairs for the prediction of unfavourable outcome were 33.3/100% and 55.6/100% for ICP and CPP, respectively, amongst patients suffering TBI and were 46.2/100% and 66.2/100% for ICP and CPP, respectively, amongst all patients.

CONCLUSION:

ICP and CPP are accurate predictors of unfavourable outcome.

PMID:
17712566
DOI:
10.1007/s00381-007-0461-z
[Indexed for MEDLINE]

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