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Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7.

Autophagy: from phenomenology to molecular understanding in less than a decade.

Author information

1
Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, USA. klionsky@umich.edu

Abstract

In 2000, it was suggested to me that "Autophagy will be the wave of the future; it will become the new apoptosis." Few people would have agreed at the time, but this statement turned out to be prophetic, and this process of 'self-eating' rapidly exploded as a research field, as scientists discovered connections to cancer, neurodegeneration and even lifespan extension. Amazingly, the molecular breakthroughs in autophagy have taken place during only the past decade.

PMID:
17712358
DOI:
10.1038/nrm2245
[Indexed for MEDLINE]

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