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Obesity (Silver Spring). 2007 Aug;15(8):1925-9.

The influence of weight loss on serum osteoprotegerin concentration in obese perimenopausal women.

Author information

1
Department of Pathophysiology, Medical University of Silesia in Katowice, ul. Medyków 18, 40-752 Katowice, Poland. holomed@poczta.onet.pl

Abstract

OBJECTIVE:

To assess the influence of weight reduction therapy on serum osteoprotegerin (OPG) concentration in obese patients and compare these results with normal-weight controls.

RESEARCH METHODS AND PROCEDURES:

Forty-three obese women (BMI, 36.7 +/- 4.1 kg/m2; mean age, 50.1 +/- 4.5 years) were studied. The control group consisted of 19 normal-weight women (BMI, 24.2 +/- 2.1 kg/m2; mean age, 53.8 +/- 5.2 years). In all patients, serum concentrations of OPG, C telopeptide of type I collagen containing the cross-linking site (CTX), osteocalcin, parathormone, 25-(OH)-D3 (vitamin D), and total calcium and phosphorus were assessed before and after a 3-month weight reduction therapy.

RESULTS:

In obese subjects, serum concentrations of OPG, 25-(OH)-D3, osteocalcin, total calcium, and phosphorus were significantly lower, and serum concentration of parathormone was significantly higher, before weight reduction therapy in comparison with normal-weight controls. After weight reduction, a significantly higher serum concentration of 25-(OH)-D3 and CTX and significantly lower concentration of OPG were found.

DISCUSSION:

Serum concentration of OPG was significantly lower in obese patients in comparison with normal-weight controls. Weight reduction therapy resulted in further decrease in OPG serum concentrations. Therefore, OPG cannot be treated as a protective factor from bone loss in obese patients.

PMID:
17712108
DOI:
10.1038/oby.2007.229
[Indexed for MEDLINE]
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