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Antimicrob Agents Chemother. 2007 Nov;51(11):4202-4. Epub 2007 Aug 20.

In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor.

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  • 1Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden. emma.huitric@smi.ki.se

Abstract

The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC(50) for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 microg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes.

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