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J Leukoc Biol. 2007 Dec;82(6):1375-81. Epub 2007 Aug 20.

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation.

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1
Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium.

Abstract

The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

PMID:
17709402
DOI:
10.1189/jlb.0607338
[Indexed for MEDLINE]
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