Format

Send to

Choose Destination
Trends Cell Biol. 1997 Jun;7(6):220-5.

A model for sperm-egg binding and fusion based on ADAMs and integrins.

Abstract

Once a sperm meets an egg, several events must occur in order for fertilization to proceed. Sperm must bind to the zona pellucida, undergo the acrosome reaction, penetrate the zona pellucida and then bind to and fuse with the egg plasma membrane. Shortly thereafter, the egg must be activated for zygotic development. This review focuses on mammalian sperm-egg plasma membrane binding and fusion, and in particular on the roles of two families of cell-adhesion molecules, ADAMs and integrins, in this important union.

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center