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Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):163-6.

Is the blood-brain barrier relevant in metastatic germ cell tumor?

Author information

1
Department of Medicine, Division of Hematology and Oncology, Indiana University, Indianapolis, IN, USA. jazar@iupui.edu

Abstract

PURPOSE:

Germ cell tumors are uniquely chemosensitive and curable, even with advanced metastatic disease. Central nervous system recurrence can terminate a complete remission in other chemosensitive tumors, such as small cell lung cancer, because of the blood-brain barrier (BBB). We propose to document that the BBB is also relevant in germ cell tumors despite their dramatic chemosensitivity.

METHODS AND MATERIALS:

We present five cases illustrating the concept of the BBB in patients with metastatic testicular cancer treated with chemotherapy.

RESULTS:

In our large series of patients with metastatic testicular cancer treated with chemotherapy, we identified 5 unique patients. These patients were rendered free of disease only to experience relapse in the brain alone. This included 1 patient who initially had good-risk metastatic disease by means of the International Germ Cell Collaborative Group staging system at the onset of chemotherapy.

CONCLUSIONS:

The BBB is relevant in patients with metastatic testicular cancer.

PMID:
17707269
DOI:
10.1016/j.ijrobp.2007.02.042
[Indexed for MEDLINE]

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