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Compr Psychiatry. 2007 Sep-Oct;48(5):436-40. Epub 2007 Jul 5.

Worsening of psychosis in schizophrenia is longitudinally associated with tardive dyskinesia in the European Schizophrenia Outpatient Health Outcomes study.

Author information

1
Psychiatric Center Altrecht, Den Dolder, The Netherlands. d.tenback@altrecht.nl

Abstract

OBJECTIVE:

The objective of the study was to examine if worsening of psychosis predicts the emergence of tardive dyskinesia (TD).

METHOD:

Global measures of TD and Clinical Global Impression (CGI) overall symptom severity score were rated in 4 assessments in 12 months. In a risk set free of TD at baseline, associations between TD onset and change in CGI scores were assessed using Cox proportional hazard regression.

RESULTS:

A total of 8,620 patients yielded 23,565 follow-up observations, 8.8% of which represented a worsening in CGI overall symptom severity relative to the previous observation, yielding an incidence of TD of 5.2%, compared with 2.7% in observations without worsening of psychopathology (rate ratio, 1.9; 95% confidence interval, 1.3-2.7). Incidence of TD was longitudinally associated with a worsening of the CGI overall symptom severity in the months preceding TD onset (adjusted hazard ratio over 6 levels of CGI score, 1.3; 95% confidence interval, 1.1-1.4).

CONCLUSION:

Worsening in overall psychopathology in schizophrenia is longitudinally associated with the emergence of TD as measured by CGI overall symptom severity.

PMID:
17707251
DOI:
10.1016/j.comppsych.2007.05.003
[Indexed for MEDLINE]
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