Format

Send to

Choose Destination
See comment in PubMed Commons below
Expert Rev Proteomics. 2007 Aug;4(4):465-78.

Histone proteomics and the epigenetic regulation of nucleosome mobility.

Author information

1
Syracuse University, Department of Biology, Syracuse, New York, NY 13244, USA. mscosgro@syr.edu

Abstract

Chromatin structure plays a vital role in the transmission of heritable gene expression patterns. The recent application of mass spectrometry to histone biology provides several striking insights into chromatin regulation. The continuing identification of new histone post-translational modifications is revolutionizing the ways in which we think about how access to genomic DNA is controlled. While post-translational modifications of the flexible histone tails continue to be an active area of investigation, the recent discovery of multiple modifications in the structured globular domains of histones provides new insights into how the nucleosome works. Recent experiments underscore the importance of a subgroup of these modifications: those that regulate histone-DNA interactions on the lateral surface of the nucleosome. This information highlights an emerging new paradigm in chromatin control, that of the epigenetic regulation of nucleosome mobility.

PMID:
17705705
DOI:
10.1586/14789450.4.4.465
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center