Format

Send to

Choose Destination
Nat Rev Neurosci. 2007 Sep;8(9):712-23.

The effect of neurodegenerative diseases on the subventricular zone.

Author information

1
Institute of Neuroscience and Physiology at Sahlgrenska Academy, Medicinaregat 11, Box 432, s-40530 Göteborg, Sweden. maurice.curtis@neuro.gu.se

Abstract

During brain development, one of the most important structures is the subventricular zone (SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.

PMID:
17704813
DOI:
10.1038/nrn2216
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center