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J Clin Virol. 2007 Oct;40(2):156-9. Epub 2007 Aug 20.

Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients.

Author information

1
Department of Internal Medicine B, Hadassah Medical Center, Jerusalem, Israel. anatscheiman@yahoo.com

Abstract

BACKGROUND:

EBV associated hemophagocytic syndrome (HPS) is an aggressive and potentially life-threatening condition. So far, most EBV associated HPS has been characterized mainly in infants and children in Asian countries.

RESULTS:

Here, we report six cases of EBV associated HPS occurring in previously healthy adults in a non-endemic area within a short period of 3 years. All patients presented with fever, hepatosplenomegaly and pancytopenia as well as disturbed liver function tests and coagulopathy. Half were diagnosed as having lymphoma. While EBV-specific serological assays were non-diagnostic in four of the six patients, the presence of EBV DNA in plasma allowed the diagnosis of EBV associated HPS in all patients.

CONCLUSION:

EBV associated HPS may be more prevalent in non-Japanese adults than was previously considered. Screening for hemophagocytic syndrome, in adults as well as in children, should include real-time PCR for EBV.

PMID:
17703994
DOI:
10.1016/j.jcv.2007.06.014
[Indexed for MEDLINE]
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