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Brain Behav Immun. 2008 Jan;22(1):52-5. Epub 2007 Aug 20.

Cytomegalovirus is associated with depression and anxiety in older adults.

Author information

1
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. A.C.Phillips@bham.ac.uk

Abstract

Infection with cytomegalovirus (CMV), a beta-herpesvirus, is common within the population. Although asymptomatic, infection is associated with increased serum concentrations of cytokines such as TNFalpha and IL-6, which are also related to mood and wellbeing. The present study examined whether infection with CMV was associated with mood in a community-based sample of older adults. Blood samples and scores on the General Health Questionnaire were available for 137 participants. Serum was analysed for the presence of CMV-specific IgG and the antibody titre was used as an indirect measure of viral load. The majority of the participants (66%) were CMV-seropositive and seropositive status was not associated with psychological morbidity. However, within the CMV-positive group, individuals with higher CMV-specific antibody titres were more likely to be depressed, anxious, and suffer more overall psychological morbidity. This association could be mediated by the impact of affect-moderating cytokines secreted through the CMV-specific immune response.

PMID:
17703915
DOI:
10.1016/j.bbi.2007.06.012
[Indexed for MEDLINE]

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