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Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):535-44. Epub 2007 Aug 16.

Innate immune evasion by hepatitis C virus and West Nile virus.

Author information

1
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Abstract

Antiviral immunity in mammals involves several levels of surveillance and effector actions by host factors to detect viral pathogens, trigger alpha/beta interferon production, and to mediate innate defenses within infected cells. Our studies have focused on understanding how these processes are regulated during infection by hepatitis C virus (HCV) and West Nile virus (WNV). Both viruses are members of the Flaviviridae and are human pathogens, but they each mediate a very different disease and course of infection. Our results demonstrate common and unique innate immune interactions of each virus that govern antiviral immunity and demonstrate the central role of alpha/beta interferon immune defenses in controlling the outcome of infection.

PMID:
17702639
PMCID:
PMC2757293
DOI:
10.1016/j.cytogfr.2007.06.006
[Indexed for MEDLINE]
Free PMC Article

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