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Mol Cell Neurosci. 2007 Sep;36(1):47-58. Epub 2007 Jul 21.

Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle.

Author information

1
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. hlee@caltech.edu

Abstract

Elucidating mechanisms that differentiate motor neurons from interneurons are fundamental to understanding CNS development. Here we demonstrate that within the Drosophila NB 7-3/serotonergic lineage, different levels of Zfh-1 are required to specify unique properties of both motor neurons and interneurons. We present evidence that Zfh-1 is induced by Notch signaling and suppressed by the transcription factor Eagle. The antagonistic regulation of zfh-1 by Notch and Eagle results in Zfh-1 being expressed at low levels in the NB 7-3 interneurons and at higher levels in the NB 7-3 motor neurons. Furthermore, we present evidence that the induction of Zfh-1 by Notch occurs independently from canonical Notch signaling. We present a model where the differentiation of cell fates within the NB 7-3 lineage requires both canonical and non-canonical Notch signaling. Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion.

PMID:
17702602
PMCID:
PMC2716093
DOI:
10.1016/j.mcn.2007.05.011
[Indexed for MEDLINE]
Free PMC Article

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