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Curr Opin Immunol. 2007 Aug;19(4):441-7. Epub 2007 Aug 16.

Interleukin-12 and tuberculosis: an old story revisited.

Author information

1
The Trudeau Institute, Inc. 154 Algonquin Ave. Saranac Lake, NY 12983, USA. acooper@trudeauinstitute.org

Abstract

Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL-12 family of cytokines. Recent data show that IL-12, IL-23 and IL-27 have specific roles in the initiation, expansion and control of the cellular response to tuberculosis. Specifically, IL-12, and to a lesser degree IL-23, generates protective cellular responses and promotes survival, whereas IL-27 moderates the inflammatory response and is required for long-term survival. Paradoxically, IL-27 also limits bacterial control, suggesting that a balance between bacterial killing and tissue damage is required for survival. Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis.

PMID:
17702558
PMCID:
PMC2075090
DOI:
10.1016/j.coi.2007.07.004
[Indexed for MEDLINE]
Free PMC Article

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