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Amyloid. 2007 Sep;14(3):185-97.

Small molecule inhibitors of Abeta assembly.

Author information

1
Department of Molecular and Cellular Biochemistry, Chandler School of Medicine and the Center on Aging, University of Kentucky, KY, USA. hlevine@email.uky.edu

Abstract

The Abeta peptide assembles into a variety of distinct types of structures in vitro and in the brain which have different biological consequences. Differential effects of inhibitory small molecules suggest that a sequential monomer - oligomer - fibril mechanism is overly simplistic and that soluble toxic oligomers and fibrils can be formed in common or separate pathways depending on the local environment. As a result, the effects of inhibitors are often assay-dependent because multiple pathways are operating. This review discusses strategies for teasing apart the intricate protein-protein interactions that result in Abeta assembly.

PMID:
17701466
DOI:
10.1080/13506120701461020
[Indexed for MEDLINE]

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