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Mol Biosyst. 2007 Sep;3(9):598-603. Epub 2007 Jul 11.

A genome-scale, constraint-based approach to systems biology of human metabolism.

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  • 1University of California, San Diego, 9500 Gilman Dr. 0412, La Jolla, CA 92093-0412, USA.


The recent sequencing and annotation of the human genome enables a new era in biomedicine that will be based on an interdisciplinary, systemic approach to the elucidation and treatment of human disease. Reconstruction of genome-scale metabolic networks is an important part of this approach since networks represent the integration of diverse biological data such as genome annotations, high-throughput data, and legacy biochemical knowledge. This article will describe Homo sapiens Recon 1, a functionally tested, genome-scale reconstruction of human cellular metabolism, and its capabilities for facilitating the understanding of physiological and disease metabolic states.

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