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Physiology (Bethesda). 2007 Aug;22:261-8.

ER-mitochondria communication. How privileged?

Author information

  • 1Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. armstroc@mail.med.upenn.edu

Abstract

Mitochondria have a low affinity for Ca(2+), but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry into the cell and of internal Ca(2+) release. This gives mitochondria privileged access to cytoplasmic Ca(2+) without requiring a direct communication with the endoplasmic reticulum.

PMID:
17699879
DOI:
10.1152/physiol.00017.2007
[PubMed - indexed for MEDLINE]
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