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J Antimicrob Chemother. 1991 Jul;28(1):79-86.

The penetration of cefpirome into the potential sites of pulmonary infection.

Author information

1
Department of Thoracic Medicine, Dudley Road Hospital, Birmingham, UK.

Abstract

The concentrations of cefpirome, a new semi-synthetic cephalosporin, in the bronchial mucosa and serum were assessed after a single 1 g intravenous dose in 37 patients. Bronchoalveolar lavage allowed epithelial lining fluid (ELF) concentrations to be measured in eight subjects. The mean concentration for serum was 34.5 mg/L (S.E.M. 3.3), for bronchial mucosa 19.3 mg/kg (S.E.M. 1.9) and for ELF 7.2 mg/L (S.E.M. 1.1). The progressive reduction in cefpirome concentration in serum compared to that in bronchial mucosa and ELF is consistent with the permeability characteristics of beta-lactam antimicrobials and the barriers to movement of antimicrobial agents present in the lung.

PMID:
1769946
DOI:
10.1093/jac/28.1.79
[Indexed for MEDLINE]

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