Format

Send to

Choose Destination
See comment in PubMed Commons below
J Proteome Res. 2007 Sep;6(9):3705-17. Epub 2007 Aug 15.

Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.

Author information

  • 1Department of Medical Biochemistry and Biophysics, and Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

Abstract

Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previously proposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, and functionally impaired key regulator genes for buccal/oral carcinoma.

PMID:
17696463
DOI:
10.1021/pr070308q
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center