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Anticancer Res. 2007 Jul-Aug;27(4C):2917-24.

Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor.

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1
Institute of Pathology, Charité Campus Mitte, Charitéplatz 1, D-10117, Germany.

Abstract

BACKGROUND:

Numerous experimental studies have described the capacity of myofibroblasts to stimulate mammary cancer cells in a paracrine manner. Until now, the prognostic significance of myofibroblasts present in breast cancer has not been examined.

PATIENTS AND METHODS:

In paraffin sections, originating from 45 patients with primary invasive breast cancer, immunohistochemical reactions were performed using antibodies directed against smooth muscle actin, Ki-67, VEGF, bFGF and UPA.

RESULTS:

The cases with higher content of myofibroblasts in the tumour tissue manifested higher grade, more pronounced expression of Ki-67, VEGF and bFGF and shorter overall survival and relapse-free survival.

CONCLUSION:

The present study for the first time documents the unfavourable prognostic significance of myofibroblasts in tissues of invasive ductal mammary carcinomas.

PMID:
17695471
[Indexed for MEDLINE]
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