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Nihon Rinsho. 2007 Aug;65(8):1423-32.

[Clinical typing and diagnosis of sporadic human prion diseases (classic sproadic CJD, MM2-cortical form CJD, MM2-thalamic form CJD)].

[Article in Japanese]

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First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University.


We described recent knowledge and outline about a diagnosis and clinical typing of sporadic prion disease. Diagnostic procedure and classification based on a pattern of Western blotting of PrP(Sc), neuropathologic findings, and clinical features. In addition, we described a clinical significance of total tau protein, significance of a diffusion-weighted images of MRI. Analysis of 112 cases of sporadic prion diseases showed 92.3% at positive rate. Sensitivity and specificity were 95.5% and 95.7%, respectively by total tau protein assay of 44 cases of prion diseases.

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