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Neuro Endocrinol Lett. 2007 Aug;28(4):507-12.

Homocysteine, folic acid and vitamin B12 concentration in patients with recurrent miscarriages.

Author information

1
Department of Obstetrics and Gynecology, Silesian Medical University, ul. Medyków 14, 40-752 Katowice, Poland. jerzy_sikora@poczta.onet.pl

Abstract

OBJECTIVES:

The aim of the project was the assessment of clinical usefulness of the determination of blood serum homocysteine concentration, folic acid and vitamin B12 in recurrent miscarriages.

METHODS:

30 non-pregnant women with recurrent miscarriages (examined group-I) and for 20 non-pregnant women without obstetric failures in medical history (control group-II) were examined.

RESULTS:

In the examined group (group I), the average concentration of homocysteine (9,45 micromol/l) was not statistically higher in comparison to the control group (group II) (8,47 micromol/l) (p>0,05). In group I the average vitamin B12 concentration in blood serum was 178,3 pg/ml and it was statistically lower (p<0,001) in comparison with the control group (II) (268,6 pg/ml). Such a relation was not observed for the vitamin B12, where the average concentration of this parameter was not dependent on the miscarriage number. A high negative correlation (R= -0,5397, p<0,01) was observed between the level of folic acid and homocysteine concentration in the group of women with recurrent miscarriages and a very high negative correlation (r = -0,9586 p<0,001) in the control group. No relation (R=0,0992 p>0,05) between the average concentration of vitamin B12 in blood serum and the average homocysteine in the nullipara group with recurrent miscarriages

CONCLUSIONS:

Together with the increasing number of abortions, the average homocysteine concentrations grew and the average folic acid concentrations lowered.

PMID:
17693963
[Indexed for MEDLINE]

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