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Curr Opin Nephrol Hypertens. 2007 Sep;16(5):403-8.

Baroreflex stimulation in the treatment of hypertension.

Author information

1
Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642-8679, USA.

Abstract

PURPOSE OF REVIEW:

It is not uncommon for hypertension to be resistant to the effects of medical therapy, and this poses a significant risk of adverse cardiovascular events. Electrical stimulation of the carotid sinus is a novel treatment for hypertension, and has been shown to reduce blood pressure by activating the baroreflex and reducing sympathetic tone.

RECENT FINDINGS:

Evidence suggests that the baroreceptors play a more important role in long-term blood pressure regulation than was once believed. It appears that the baroreflex attenuates chronic hypertension in large part by inhibiting renal sympathetic tone. Animal and human studies have demonstrated a safe and effective lowering of blood pressure with chronic electrical stimulation of the carotid sinus, and have generated enthusiasm for implantable carotid sinus stimulators in the treatment of hypertension.

SUMMARY:

Electrical baroreflex stimulation appears safe and effective, and may represent a useful adjunct to medical therapy in patients with resistant hypertension.

PMID:
17693753
DOI:
10.1097/MNH.0b013e3282f01e4b
[Indexed for MEDLINE]
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