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CNS Neurol Disord Drug Targets. 2007 Aug;6(4):247-50.

GABAergic drugs for the treatment of migraine.

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Department of Neurology, Cologne City Hospitals, University of Cologne, Germany.


Within the last decades significant progress has been made in the understanding of the underlying pathophysiological mechanisms of migraine. There is a general agreement now that migraine is not only a vascular phenomenon but also a genetically determined heterogenic ion-channelopathy resulting in cortical-spreading-depression-like events, the temporary impairment of antinociceptive structures of the brainstem and the activation of the trigeminal-vascular system. The development and use of drugs targeting ion-channels and subsequently reducing cortical excitability appears as a promising avenue for both the acute treatment of migraine and migraine prevention. This review summarizes the current knowledge and evidence for GABAergic drugs in the treatment of migraine.

[Indexed for MEDLINE]

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