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Acta Neurochir Suppl. 2007;97(Pt 2):357-62.

A novel closed-loop stimulation system in the control of focal, medically refractory epilepsy.

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Department of Neurosurgery, Medical College of Georgia, Augusta, GA, USA.


The concept of seizure abortion after prompt detection by employing stimulation is a very appealing one. Several investigators in previous experimental and clinical studies have used stimulation of various anatomical targets with promising results. In this chapter, the authors present their experience with a novel, implantable, local closed-loop responsive neuro-stimulation system (RNS) (Neuropace, Inc., Mountain View, CA, USA). This system consists of a cranially implanted pulse generator, one or two quadripolar subdural strip or depth leads and an external programmer. The system components and technical characteristics are presented. The criteria for selecting candidates for implantation as well as the preliminary results of a clinical trial are also presented. Closed-loop stimulation system appears to be a safe treatment option with promising results for the management of patients with well-localized, focal medically-refractory epilepsy, who are not candidates for surgical resection.

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