A novel antiplasmodial 3',5'-diformylchalcone and other constituents of Friesodielsia obovata

Cosam C Joseph; Joseph J Magadula; Mayunga H H Nkunya

doi:10.1080/14786410701194310

A novel antiplasmodial 3',5'-diformylchalcone and other constituents of Friesodielsia obovata

Nat Prod Res. 2007 Sep;21(11):1009-15. doi: 10.1080/14786410701194310.

Authors

Cosam C Joseph¹, Joseph J Magadula, Mayunga H H Nkunya

Affiliation

¹ Department of Chemistry, University of Dar es Salaam, Dar es Salaam, Tanzania. cosam@chem.udsm.ac.tz

PMID: 17691050
DOI: 10.1080/14786410701194310

Abstract

Phytochemical investigation of the stem and root barks of Friesodielsia obovata Benth (Annonaceae) afforded new 3',5'-diformyl-2',4',6'-trihydroxychalcone and N-formyl-7-hydroxyglaucine together with five known compounds, 3',5'-dimethyl-2',4',6'-trihydroxychalcone, (-)-crotepoxide, demethoxymatteucinol, lawinal, and benzyl benzoate. 3',5'-diformyl-2',4',6'-trihydroxychalcone indicated significant antiplasmodial, cytotoxicity, and larvicidal activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Annonaceae / chemistry*
Anopheles / drug effects
Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / pharmacology*
Artemia / drug effects
Chalcones / chemistry
Chalcones / isolation & purification*
Chalcones / pharmacology*
Larva / drug effects
Molecular Structure
Plant Bark / chemistry
Plants, Medicinal / chemistry*
Plasmodium falciparum / drug effects*
Tanzania

Substances

3',5'-diformylchalcone
Antimalarials
Chalcones