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Am J Respir Crit Care Med. 2007 Nov 1;176(9):871-7. Epub 2007 Aug 9.

Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice.

Author information

1
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil.

Abstract

RATIONALE:

Aerobic conditioning improves exercise capacity and decreases symptoms in patients with asthma. However, its benefits in the context of allergic airway inflammation are poorly understood.

OBJECTIVES:

To evaluate the effects of two intensities of aerobic exercise on airway inflammation and remodeling in a model of chronic allergic lung inflammation.

METHODS:

Mice were subjected to chronic ovalbumin (OVA) sensitization and to 4 weeks of low (OVA+Low) or moderate (OVA+Mod) exercise training in a treadmill. Airway inflammation and remodeling and expression of helper T-cell type 1 and 2 cytokines were evaluated.

MEASUREMENTS AND MAIN RESULTS:

OVA-induced allergic airway inflammation and remodeling were characterized by an increase in collagen (288%), elastic fiber (56%), smooth muscle (380%), and epithelial (402%) contents (P < 0.001) when compared with the control group. OVA+Low and OVA+Mod groups presented a decrease in bronchoalveolar lavage fluid eosinophils (respectively, 84 and 75%; P < 0.01) and airway walls (respectively, 94 and 58%; P < 0.001) when compared with the OVA group. OVA+Low and OVA+Mod groups also presented a reduction in the number of peribronchial inflammatory cells expressing IL-4 (respectively, 85 and 75%; P < 0.01) and IL-5 (respectively, 88 and 89%; P < 0.01) when compared with the OVA group. Aerobic conditioning did not change the expression of either IFN-gamma or IL-2 by inflammatory cells or plasma levels of IgE or IgG1. OVA+Low and OVA+Mod groups presented an increase in the expression of IL-10 (P < 0.001). Low and moderate aerobic conditioning also reduced airway remodeling in OVA-sensitized mice when compared with the OVA group.

CONCLUSIONS:

We concluded that low and moderate aerobic exercise decreases airway inflammation and remodeling in a murine model of asthma.

PMID:
17690332
DOI:
10.1164/rccm.200610-1567OC
[Indexed for MEDLINE]

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