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Epidemiol Infect. 2008 May;136(5):577-603. Epub 2007 Aug 9.

Part II. Analysis of data gaps pertaining to Shigella infections in low and medium human development index countries, 1984-2005.

Author information

1
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA. pkram@buffalo.edu

Abstract

The global incidence of Shigella infection has been estimated at 80-165 million episodes annually, with 99% of episodes occurring in the developing world. To identify contemporary gaps in the understanding of the global epidemiology of shigellosis, we conducted a review of the English-language scientific literature from 1984 to 2005, restricting the search to low and medium human development countries. Our review yielded 11 population-based studies of Shigella burden from seven countries. No population-based studies have been conducted in sub-Saharan Africa or in low human development countries. In studies done in all age groups, Shigella incidence varied from 0.6 to 107 episodes/1000 person-years. S. flexneri was the most commonly detected subgroup in the majority of studies. Case-fatality rates ranged from 0% to 2.6% in population-based studies and from 0% to 21% in facility-based studies. This review highlights the large gaps in data on the burden of Shigella infections for low human development index countries and, more specifically, for sub-Saharan Africa.

PMID:
17686195
PMCID:
PMC2870860
DOI:
10.1017/S0950268807009351
[Indexed for MEDLINE]
Free PMC Article

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