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Mol Biol (Mosk). 2007 May-Jun;41(3):433-49.

[C-terminal domain (CTD) of the subunit Rpb1 of nuclear RNA polymerase II and its role in the transcription cycle].

[Article in Russian]


The review deals with analysis of the structure, functions and molecular evolution of the CTD (C-terminal domain) of the largest subunit Rpb1 of nuclear RNA polymerase II. All the discovered ways of CTD modifications are summarized. Its interactions with various partners are described in the context of the CTD central role in coupling of the major transcription steps (initiation, elongation and termination) with the main stages of pre-mRNA processing (capping, splicing and polyadenylation) in eukaryotes during different stages of the cell cycle.

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