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BMC Med Genet. 2007 Aug 3;8:51.

The TCF7L2 locus and type 1 diabetes.

Author information

1
Endocrine Genetics Lab, The McGill University Health Center, Montreal Children's Hospital, Montréal, Québec, Canada. hui.qi.qu@mail.mcgill.ca

Abstract

BACKGROUND:

TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D).

METHODS:

The SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent.

RESULTS:

This study found no T1D association with, and no age-of-onset effect from rs7903146.

CONCLUSION:

This study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.

PMID:
17683561
PMCID:
PMC1978206
DOI:
10.1186/1471-2350-8-51
[Indexed for MEDLINE]
Free PMC Article

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