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Clin Infect Dis. 2007 Sep 1;45(5):e46-51. Epub 2007 Jul 23.

Community-acquired recurrent bacterial meningitis in adults.

Author information

1
Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. k.s.adriani@amc.uva.nl

Abstract

BACKGROUND:

Community-acquired recurrent bacterial meningitis in adults is a relatively rare disease. All previous data were derived from small retrospective case series.

METHODS:

We prospectively evaluated episodes of recurrent bacterial meningitis in a nationwide cohort study in The Netherlands.

RESULTS:

Thirty-four episodes of recurrent bacterial meningitis were identified among 31 patients; 3 patients experienced 2 episodes during the study period. The mean age was 43 years, and 25 (74%) of 34 episodes occurred in men. Predisposing conditions were involved in 26 (77%) of 34 episodes; the most common predisposing conditions were remote head injury (17 [53%] of 32 episodes) and cerebrospinal fluid (CSF) leakage (9 [32%] of 28 episodes). Lumbar puncture revealed an individual CSF indicator of bacterial meningitis for almost all episodes (88%). The outcome was death for 5 (15%) of 34 episodes; 1 additional patient had a suboptimal score on the Glasgow Outcome Scale.

CONCLUSION:

We conclude that most patients with recurrent meningitis are male and have predisposing conditions, which, in most cases, are remote head injury or CSF leakage.

PMID:
17682979
DOI:
10.1086/520682
[Indexed for MEDLINE]

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