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Gastroenterology. 2007 Aug;133(2):539-46. Epub 2007 May 21.

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

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1
Department of Molecular Geneticsm, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA.

Abstract

BACKGROUND AND AIMS:

The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell lineages. In the intestine, Sox9 is expressed in the epithelial cells of the crypts and is a target of Wnt signaling.

METHODS:

To examine the function of SOX9 in the intestine, we inactivated the Sox9 gene in intestinal epithelial cells by generating mice that harbored a conditional Sox9 gene and a Villin-Cre transgene.

RESULTS:

In the absence of SOX9, Paneth cells were not formed, but the differentiation of other intestinal epithelial cell types was unaffected. The lack of SOX9 also lead to crypt enlargement, to a marked increase in cell proliferation throughout the crypts, and to replacement of the Paneth cells by proliferating epithelial cells.

CONCLUSIONS:

We conclude that SOX9 is required for the differentiation of Paneth cells. Our results elucidate an essential step in the differentiation of gut epithelium.

PMID:
17681175
DOI:
10.1053/j.gastro.2007.05.020
[Indexed for MEDLINE]
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