Abstract
In this retrospective cohort study of 102 ovarian stimulation cycles for IVF/intracytoplasmic sperm injection using GnRH antagonist and gonadotropins, we sought to assess the effect of high E(2) levels on endometrial stripe thickness and its association with pregnancy outcomes and serum E(2) levels. We found no significant correlation between serum E(2) levels (both peak and area under the curve E(2) concentration) and the endometrial thickness. However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%).
MeSH terms
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Abortion, Spontaneous / blood
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Abortion, Spontaneous / diagnosis*
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Abortion, Spontaneous / pathology
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Adult
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Cohort Studies
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Down-Regulation
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Embryo Transfer
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Endometrium / drug effects*
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Endometrium / pathology
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Estradiol / blood*
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Female
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Fertility Agents, Female / pharmacology
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Fertility Agents, Female / therapeutic use*
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Fertilization in Vitro
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Gonadotropin-Releasing Hormone / antagonists & inhibitors*
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Gonadotropins / therapeutic use
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Hormone Antagonists / pharmacology
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Hormone Antagonists / therapeutic use*
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Humans
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Infertility / blood
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Infertility / pathology
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Infertility / therapy*
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Ovulation Induction / adverse effects*
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Ovulation Induction / methods
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Pregnancy
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Pregnancy Outcome
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Pregnancy Rate
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Retrospective Studies
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Sensitivity and Specificity
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Sperm Injections, Intracytoplasmic
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Treatment Outcome
Substances
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Fertility Agents, Female
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Gonadotropins
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Hormone Antagonists
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Gonadotropin-Releasing Hormone
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Estradiol