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Nat Neurosci. 2007 Sep;10(9):1128-30. Epub 2007 Aug 5.

Cell type-specific gating of perisomatic inhibition by cholecystokinin.

Author information

1
Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280, USA. cfoldy@uci.edu

Abstract

Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.

PMID:
17676058
DOI:
10.1038/nn1952
[Indexed for MEDLINE]

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