Format

Send to

Choose Destination
See comment in PubMed Commons below
J Inorg Biochem. 2007 Sep;101(9):1291-338. Epub 2007 Jun 12.

Does neurotransmission impairment accompany aluminium neurotoxicity?

Author information

1
Departamento de Biologia, Campus Universitário de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal. pgoncalves@bio.ua.pt

Abstract

Neurobehavioral disorders, except their most overt form, tend to lie beyond the reach of clinicians. Presently, the use of molecular data in the decision-making processes is limited. However, as details of the mechanisms of neurotoxic action of aluminium become clearer, a more complete picture of possible molecular targets of aluminium can be anticipated, which promises better prediction of the neurotoxicological potential of aluminium exposure. In practical terms, a critical analysis of current data on the effects of aluminium on neurotransmission can be of great benefit due to the rapidly expanding knowledge of the neurotoxicological potential of aluminium. This review concludes that impairment of neurotransmission is a strong predictor of outcome in neurobehavioral disorders. Key questions and challenges for future research into aluminium neurotoxicity are also identified.

PMID:
17675244
DOI:
10.1016/j.jinorgbio.2007.06.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center