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Biochim Biophys Acta. 2008 Sep;1778(9):1930-45. Epub 2007 Jun 15.

Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors.

Author information

1
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

A variety of mechanisms are used to signal extracytoplasmic conditions to the cytoplasm. These mechanisms activate extracytoplasmic function (ECF) sigma factors which recruit RNA-polymerase to specific genes in order to express appropriate proteins in response to the changing environment. The two best understood ECF signaling pathways regulate sigma(E)-mediated expression of periplasmic stress response genes in Escherichia coli and FecI-mediated expression of iron-citrate transport genes in E. coli. Homologues from other Gram-negative bacteria suggest that these two signaling mechanisms and variations on these mechanisms may be the general schemes by which ECF sigma factors are regulated in Gram-negative bacteria.

PMID:
17673165
PMCID:
PMC2562455
DOI:
10.1016/j.bbamem.2007.06.005
[Indexed for MEDLINE]
Free PMC Article

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