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J Clin Invest. 2007 Aug;117(8):2059-66.

Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications.

Author information

1
Department of Molecular Virology, Immunology and Medical Genetics, Colleges of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.

Abstract

There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.

PMID:
17671640
PMCID:
PMC1934569
DOI:
10.1172/JCI32577
[Indexed for MEDLINE]
Free PMC Article

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