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J Virol. 2007 Oct;81(19):10815-7. Epub 2007 Aug 1.

Induction of autophagy does not affect human rhinovirus type 2 production.

Author information

1
Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

Abstract

Induction of autophagy has been shown to be beneficial for the replication of poliovirus, a phenomenon that might also apply for other picornaviruses. We demonstrate that de novo synthesis of human rhinovirus type 2 (HRV2), an HRV of the minor receptor group, is unaffected by tamoxifen, rapamycin, and 3-methyladenine (3-MA), drugs either stimulating (tamoxifen and rapamycin) or inhibiting (3-MA) autophagic processes. Furthermore, LC3-positive vesicles (i.e., autophagosomes) are not induced upon infection. Therefore, multiplication of this particular picornavirus is not dependent on autophagy.

PMID:
17670838
PMCID:
PMC2045498
DOI:
10.1128/JVI.00143-07
[Indexed for MEDLINE]
Free PMC Article
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