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Interact Cardiovasc Thorac Surg. 2005 Apr;4(2):147-50. Epub 2005 Feb 18.

Is Sotalol more effective than standard beta-blockers for the prophylaxis of atrial fibrillation during cardiac surgery.

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Department of Cardiothoracic Surgery, Freeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne NE7 7AZ, UK.


A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether prophylactic Sotalol was more effective than conventional beta blockers in the prevention of atrial fibrillation after cardiac surgery. Fifty-one papers were found of which eight presented the best evidence to answer the question. The author, journal, date and country of publication, patient group, relevant outcomes and weaknesses were tabulated. We conclude that prophylactic Sotalol may be more effective than beta blockers in the prevention of post operative atrial fibrillation, and should not cause an excess of side effects.


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