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Immunol Cell Biol. 2007 Aug-Sep;85(6):435-45. Epub 2007 Jul 31.

Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response.

Author information

1
Department of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia. alexander.thompson@svhm.org.au

Abstract

The antiviral innate immune response follows the detection of viral components by host pattern recognition receptors (PRRs). Two families of PRRs have emerged as key sensors of viral infection: Toll-like receptors (TLRs) and retinoic acid inducible gene-I like RNA helicases (RLHs). TLRs patrol the extracellular and endosomal compartments; signalling results in a type-1 interferon response and/or the production of pro-inflammatory cytokines. In contrast, RLHs survey the cytoplasm for the presence of viral double-stranded RNA. In the face of such host defence, viruses have developed strategies to evade TLR/RLH signalling. Such host-virus interactions provide the opportunity for manipulation of PRR signalling as a novel therapeutic approach.

PMID:
17667934
DOI:
10.1038/sj.icb.7100100
[Indexed for MEDLINE]

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