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Pediatr Emerg Care. 2007 Jul;23(7):465-8.

Implications of diphenhydramine single-dose unintended ingestions in young children.

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College of Pharmacy, Ohio State University, Columbus, OH 43210, USA.



Diphenhydramine is frequently used in children, but the consequences of single unintended dose exposures in young children are unknown.


We evaluated 2000-2001 American Association of Poison Control Centers-Toxic Exposure Surveillance data on children exposed to diphenhydramine ingestions.


Nine hundred twenty-six cases met the inclusion criteria; 49.1% were men, mean age was 29.7 +/- 13.0 months (range, 1-72 months). Approximately 85% of unintentional exposures occurred in 1- to 3-year-old children. The mean dose ingested was 6.4 +/- 6.1 mg/kg (median, 4.6 mg/kg). Thirty-two percent of patients were symptomatic: minor (29.4%), moderate (2.9%), and severe (0.11%). There was no relationship between dose and symptom severity. Diphenhydramine dose ingestion of 7.5 mg/kg or greater was not a predictor of severity (P = 0.47)


The relationship between ingested dose and severity of symptoms was insignificant.

[Indexed for MEDLINE]

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