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Pediatr Emerg Care. 2007 Jul;23(7):465-8.

Implications of diphenhydramine single-dose unintended ingestions in young children.

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1
College of Pharmacy, Ohio State University, Columbus, OH 43210, USA.

Abstract

BACKGROUND:

Diphenhydramine is frequently used in children, but the consequences of single unintended dose exposures in young children are unknown.

METHODS:

We evaluated 2000-2001 American Association of Poison Control Centers-Toxic Exposure Surveillance data on children exposed to diphenhydramine ingestions.

RESULTS:

Nine hundred twenty-six cases met the inclusion criteria; 49.1% were men, mean age was 29.7 +/- 13.0 months (range, 1-72 months). Approximately 85% of unintentional exposures occurred in 1- to 3-year-old children. The mean dose ingested was 6.4 +/- 6.1 mg/kg (median, 4.6 mg/kg). Thirty-two percent of patients were symptomatic: minor (29.4%), moderate (2.9%), and severe (0.11%). There was no relationship between dose and symptom severity. Diphenhydramine dose ingestion of 7.5 mg/kg or greater was not a predictor of severity (P = 0.47)

CONCLUSIONS:

The relationship between ingested dose and severity of symptoms was insignificant.

[Indexed for MEDLINE]

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