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Br J Psychiatry. 2007 Aug;191:113-9.

Cortical white-matter microstructure in schizophrenia. Diffusion imaging study.

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1
Department of Medicine and Public Health, University of Verona, Italy.

Abstract

BACKGROUND:

Several, although not all, of the previous small diffusion-weighted imaging (DWI) studies have shown cortical white-matter disruption in schizophrenia.

AIMS:

To investigate cortical white-matter microstructure with DWI in a large community-based sample of people with schizophrenia.

METHOD:

Sixty-eight people with schizophrenia and 64 healthy controls underwent a session of DWI to obtain the apparent diffusion coefficient (ADC) of white-matter water molecules. Regions of interest were placed in cortical lobes.

RESULTS:

Compared with controls, the schizophrenia group had significantly greater ADCs in frontal, temporal and occipital white matter (analysis of covariance, P < 0.05).

CONCLUSIONS:

Our findings confirm the presence of cortical white-matter microstructure disruption in frontal and temporo-occipital lobes in the largest sample of people with schizophrenia thus for studied with this technique. Future brain imaging studies, together with genetic investigations, should further explore white-matter integrity and genes encoding myelin-related protein expression in people with first-episode schizophrenia and those at high risk of developing the disorder.

PMID:
17666494
DOI:
10.1192/bjp.bp.105.020990
[Indexed for MEDLINE]
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